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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 14-3-3 protein epsilon

UniprotKB/SwissProt ID: 1433E_HUMAN (P62258)

Gene Name: YWHAE

Organism: Homo sapiens (Human).

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04722Neurotrophin signaling pathway
map04110Cell cycle
map04114Oocyte meiosis
map04151PI3K-Akt signaling pathway
map05169Epstein-Barr virus infection
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000308

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2BR9 X-ray 1.75 A A1-233Link
3UAL X-ray 1.80 A A1-232Link
3UBW X-ray 1.90 A A1-234Link

The S-nitrosylation sites of 1433E_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
197QMVETELKLI C CDILDVLDKH HHHHHHHHHH H HHHHHHHHHH 2.18%HC0422178444-
297QMVETELKLI C CDILDVLDKH HHHHHHHHHH H HHHHHHHHHH 2.18%HC0419483679in vivo
398MVETELKLIC C DILDVLDKHL HHHHHHHHHH H HHHHHHHHHC 2.64%HC0822178444-
498MVETELKLIC C DILDVLDKHL HHHHHHHHHH H HHHHHHHHHC 2.64%HC0819483679in vivo