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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 14-3-3 protein epsilon

UniprotKB/SwissProt ID: 1433E_RAT (P62260)

Gene Name: Ywhae

Organism: Rattus norvegicus (Rat).

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Melanosome (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04722Neurotrophin signaling pathway
map04110Cell cycle
map04114Oocyte meiosis
map04151PI3K-Akt signaling pathway
map05169Epstein-Barr virus infection
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000308

The S-nitrosylation sites of 1433E_RAT

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1192YEILNSPDRA C RLAKAAFDDA HHHHCCHHHH H HHHHHHHHHH 3.69%RC0217629318in vitro