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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 14-3-3 protein theta

UniprotKB/SwissProt ID: 1433T_HUMAN (P27348)

Gene Name: YWHAQ

Organism: Homo sapiens (Human).

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map05130Pathogenic Escherichia coli infection
map04110Cell cycle
map04114Oocyte meiosis
map04151PI3K-Akt signaling pathway
map05161Hepatitis B
map05169Epstein-Barr virus infection
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000308

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2BTP X-ray 2.80 A A/B1-234Link

The S-nitrosylation sites of 1433T_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
125QAERYDDMAT C MKAVTEQGAE HHHHHHHHHH H HHHHHHCCCC 1.59%HC112212679in vitro
225QAERYDDMAT C MKAVTEQGAE HHHHHHHHHH H HHHHHHCCCC 1.59%HC1116648260in vivo
394EKVESELRSI C TTVLELLDKY HHHHHHHHHH H HHHHHHHHHH 2.48%HC0425040305in vivo
494EKVESELRSI C TTVLELLDKY HHHHHHHHHH H HHHHHHHHHH 2.48%HC0419483679in vivo
5134DYFRYLAEVA C GDDRKQTIDN HHHHHHHHHH C CHHHHHHHHH 8.09%HC0119101475-
6134DYFRYLAEVA C GDDRKQTIDN HHHHHHHHHH C CHHHHHHHHH 8.09%HC0119483679in vivo
7134DYFRYLAEVA C GDDRKQTIDN HHHHHHHHHH C CHHHHHHHHH 8.09%HC0120140087in vivo