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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 14-3-3 protein theta

UniprotKB/SwissProt ID: 1433T_MOUSE (P68254)

Gene Name: Ywhaq

Organism: Mus musculus (Mouse).

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04110Cell cycle
map04114Oocyte meiosis
map04151PI3K-Akt signaling pathway
map05161Hepatitis B
map05169Epstein-Barr virus infection
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000308

The S-nitrosylation sites of 1433T_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
125QAERYDDMAT C MKAVTEQGAE HHHHHHHHHH H HHHHHHCCCC 1.59%MC1124926564-
225QAERYDDMAT C MKAVTEQGAE HHHHHHHHHH H HHHHHHCCCC 1.59%MC1120925432in vivo
394EKVESELRSI C TTVLELLDKY HHHHHHHHHH H HHHHHHHHHH 2.48%MC0322588120-
4134DYFRYLAEVA C GDDRKQTIEN HHHHHHHHHH C CHHHHHHHHH 8.09%MC0119101475-
5134DYFRYLAEVA C GDDRKQTIEN HHHHHHHHHH C CHHHHHHHHH 8.09%MC0121278135in vitro