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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 14-3-3 protein zeta/delta

UniprotKB/SwissProt ID: 1433Z_HUMAN (P63104)

Gene Name: YWHAZ

Organism: Homo sapiens (Human).

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map05130Pathogenic Escherichia coli infection
map04110Cell cycle
map04114Oocyte meiosis
map04151PI3K-Akt signaling pathway
map05161Hepatitis B
map05169Epstein-Barr virus infection
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000308

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1IB1 X-ray 2.70 A A/B/C/D1-245Link
1QJA X-ray 2.00 A A/B1-245Link
1QJB X-ray 2.00 A A/B1-245Link
2C1J X-ray 2.60 A A/B1-245Link
2C1N X-ray 2.00 A A/B1-245Link
2O02 X-ray 1.50 A A/B1-230Link
2WH0 X-ray 2.25 A A/B/C/D1-245Link
3CU8 X-ray 2.40 A A/B1-245Link
3NKX X-ray 2.40 A A/B1-245Link
3RDH X-ray 2.39 A A/B/C/D1-245Link
4BG6 X-ray 2.30 A A/B1-245Link
4FJ3 X-ray 1.95 A A/B1-230Link
4HKC X-ray 2.20 A A1-245Link
4IHL X-ray 2.20 A A/B1-230Link
4N7G X-ray 2.25 A A1-230Link
4N7Y X-ray 2.16 A A/B1-230Link
4N84 X-ray 2.50 A A/B1-230Link

The S-nitrosylation sites of 1433Z_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
125QAERYDDMAA C MKSVTEQGAE HHHHHHHHHH H HHHHHHCCCC 2.27%HC112212679in vitro
225QAERYDDMAA C MKSVTEQGAE HHHHHHHHHH H HHHHHHCCCC 2.27%HC1122126794in vivo
325QAERYDDMAA C MKSVTEQGAE HHHHHHHHHH H HHHHHHCCCC 2.27%HC1125040305in vivo
494EKIETELRDI C NDVLSLLEKF HHHHHHHHHH H HHHHHHHHHH 4.10%HC0425040305in vivo
594EKIETELRDI C NDVLSLLEKF HHHHHHHHHH H HHHHHHHHHH 4.10%HC0419483679in vivo
6189YEILNSPEKA C SLAKTAFDEA HHHHCCHHHH H HHHHHHHHHH 5.19%HC0919483679in vivo