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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

UniprotKB/SwissProt ID: 2AAA_HUMAN (P30153)

Gene Name: PPP2R1A

Organism: Homo sapiens (Human).

Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Chromosome, centromere. Note=Centromeric localization requires the presence of BUB1.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04728Dopaminergic synapse
map04730Long-term depression
map05142Chagas disease (American trypanosomiasis)
map05160Hepatitis C
map03015mRNA surveillance pathway
map04114Oocyte meiosis
map04151PI3K-Akt signaling pathway
map04350TGF-beta signaling pathway
map04530Tight junction
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000357
IPR011989

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1B3U X-ray 2.30 A A/B2-589Link
2IE3 X-ray 2.80 A A1-589Link
2IE4 X-ray 2.60 A A1-589Link
2NPP X-ray 3.30 A A/D1-589Link
2NYL X-ray 3.80 A A/D8-589Link
2NYM X-ray 3.60 A A/D8-589Link
2PKG X-ray 3.30 A A/B10-589Link
3C5W X-ray 2.80 A A9-589Link
3DW8 X-ray 2.85 A A/D9-589Link
3K7V X-ray 2.85 A A1-589Link
3K7W X-ray 2.96 A A1-589Link
4I5L X-ray 2.43 A A/D9-589Link
4I5N X-ray 2.80 A A/D9-589Link
4LAC X-ray 2.82 A A404-589Link

The S-nitrosylation sites of 2AAA_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1390VRLNIISNLD C VNEVIGIRQL HHHHHHHHHH H HHHHHHHHHH 3.89%HC1219483679in vivo