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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

UniprotKB/SwissProt ID: 2AAA_MOUSE (Q76MZ3)

Gene Name: Ppp2r1a

Organism: Mus musculus (Mouse).

Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Chromosome, centromere (By similarity). Note=Centromeric localization requires the presence of BUB1 (By similarity).

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04728Dopaminergic synapse
map04730Long-term depression
map05142Chagas disease (American trypanosomiasis)
map05160Hepatitis C
map03015mRNA surveillance pathway
map04114Oocyte meiosis
map04151PI3K-Akt signaling pathway
map04350TGF-beta signaling pathway
map04530Tight junction
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000357
IPR011989

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2IAE X-ray 3.50 A A/D1-589Link
2PF4 X-ray 3.10 A A/B/C/D1-589Link
3FGA X-ray 2.70 A A2-589Link

The S-nitrosylation sites of 2AAA_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1174AELRQYFRNL C SDDTPMVRRA HHHHHHHHHC C CCCCHHHHHH 4.84%MC0121278135in vitro
2329ENVIMTQILP C IKELVSDANQ HHHHHHHHHH H HHHHHCCCCH 6.60%MC0620925432in vivo
3390VRLNIISNLD C VNEVIGIRQL HHHHHHHHHH H HHHHHHHHHH 3.89%MC0819101475-
4390VRLNIISNLD C VNEVIGIRQL HHHHHHHHHH H HHHHHHHHHH 3.89%MC0819483679in vivo
5390VRLNIISNLD C VNEVIGIRQL HHHHHHHHHH H HHHHHHHHHH 3.89%MC0821278135in vitro
6504NYLHRMTTLF C INVLSEVCGQ CCCHHHHHHH H HHHHHHHHCC 2.20%MC0122865876in vivo
7512LFCINVLSEV C GQDITTKHML HHHHHHHHHH H CCCHHHHHHH 3.39%MC0522865876in vivo