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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Eukaryotic translation initiation factor 4E-binding protein 1

UniprotKB/SwissProt ID: 4EBP1_MOUSE (Q60876)

Gene Name: Eif4ebp1

Organism: Mus musculus (Mouse).

Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map05221Acute myeloid leukemia
map04066HIF-1 signaling pathway
map04012ErbB signaling pathway
map04150mTOR signaling pathway
map04151PI3K-Akt signaling pathway
map04910Insulin signaling pathway
map03013RNA transport
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR008606

The S-nitrosylation sites of 4EBP1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
17----MSAGSS C SQTPSRAIPT ----CCCCCC C CCCCCCCCCE 3.61%MC0222865876in vivo