UniprotKB/SwissProt ID: ABCE1_HUMAN (P61221)
Gene Name: ABCE1
Synonyms: RLI, RNASEL1, RNASELI, RNS4I
Organism: Homo sapiens (Human).
Function: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane.
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