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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

UniprotKB/SwissProt ID: ACDSB_MOUSE (Q9DBL1)

Gene Name: Acadsb

Organism: Mus musculus (Mouse).

Function: Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix (Probable).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00071Fatty acid metabolism
map00280"Valine, leucine and isoleucine degradation"
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR006089
IPR006090
IPR006091
IPR006092
IPR009075
IPR009100
IPR013764
IPR013786

The S-nitrosylation sites of ACDSB_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1261NKMGIRASST C QLTFENVKVP CCCCCCCCCC C EEEEEEEECC 3.18%MC0821278135in vitro
2385SEVAGLTTSK C IEWMGGVGYT HHHHHHHHHH H HHHHCCCCCC 3.23%MC1322865876in vivo