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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: ATP-citrate synthase

UniprotKB/SwissProt ID: ACLY_HUMAN (P53396)

Gene Name: ACLY

Organism: Homo sapiens (Human).

Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00020Citrate cycle (TCA cycle)
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003781
IPR005809
IPR005810
IPR005811
IPR013816
IPR014608

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3MWD X-ray 2.10 A A1-425Link
3MWE X-ray 2.20 A A1-425Link
B487-821
3PFF X-ray 2.30 A A1-817Link

The S-nitrosylation sites of ACLY_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1229AKVDATADYI C KVKWGDIEFP ECCCCCHHHC C CCCCCCCCCC 3.18%HC062212679in vitro
2229AKVDATADYI C KVKWGDIEFP ECCCCCHHHC C CCCCCCCCCC 3.18%HC0619483679in vivo