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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: ATP-citrate synthase

UniprotKB/SwissProt ID: ACLY_MOUSE (Q91V92)

Gene Name: Acly

Organism: Mus musculus (Mouse).

Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00020Citrate cycle (TCA cycle)
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003781
IPR005809
IPR005810
IPR005811
IPR013816
IPR014608

The S-nitrosylation sites of ACLY_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
120TGKELLYKYI C TTSAIQNRFK HHHHHHHHCC C CCCCCCCCCC 2.85%MC1322178444-
220TGKELLYKYI C TTSAIQNRFK HHHHHHHHCC C CCCCCCCCCC 2.85%MC1324895380-
320TGKELLYKYI C TTSAIQNRFK HHHHHHHHCC C CCCCCCCCCC 2.85%MC1318335467-
420TGKELLYKYI C TTSAIQNRFK HHHHHHHHCC C CCCCCCCCCC 2.85%MC1319101475-
520TGKELLYKYI C TTSAIQNRFK HHHHHHHHCC C CCCCCCCCCC 2.85%MC1319366988-
620TGKELLYKYI C TTSAIQNRFK HHHHHHHHCC C CCCCCCCCCC 2.85%MC1320837516in vivo
7623PATVGGIKPG C FKIGNTGGML CCCCCCCCCC C EECCCCCCCH 4.21%MC0622178444-
8623PATVGGIKPG C FKIGNTGGML CCCCCCCCCC C EECCCCCCCH 4.21%MC0620837516in vivo
9835RKPASFMTSI C DERGQELIYA CCCHHHCCCH H HHCCCCHHCC 4.44%MC0822178444-
10835RKPASFMTSI C DERGQELIYA CCCHHHCCCH H HHCCCCHHCC 4.44%MC0820837516in vivo