Protein Name: Cytoplasmic aconitate hydratase
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UniprotKB/SwissProt ID: ACOC_MOUSE (P28271)
Gene Name: Aco1
Synonyms: Ireb1, Irebp
Organism: Mus musculus (Mouse).
Function: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity). Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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