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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Alpha-actinin-1

UniprotKB/SwissProt ID: ACTN1_MOUSE (Q7TPR4)

Gene Name: Actn1

Organism: Mus musculus (Mouse).

Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane. Cell junction. Cell projection, ruffle. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and centr

Network with metabolic pathway:
Kegg map ID Pathway Link
map05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
map04520Adherens junction
map04670Leukocyte transendothelial migration
map05146Amoebiasis
map05322Systemic lupus erythematosus
map04510Focal adhesion
map04530Tight junction
map04810Regulation of actin cytoskeleton
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001589
IPR001715
IPR002017
IPR002048
IPR011992
IPR014837

The S-nitrosylation sites of ACTN1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1332LHKPPKVQEK C QLEINFNTLQ HCCCHHHHHH H HHHHHHHHHH 5.70%MC0820925432in vivo