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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Alpha-actinin-2

UniprotKB/SwissProt ID: ACTN2_MOUSE (Q9JI91)

Gene Name: Actn2

Organism: Mus musculus (Mouse).

Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.

Network with metabolic pathway:
Kegg map ID Pathway Link
map05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
map04520Adherens junction
map04670Leukocyte transendothelial migration
map05146Amoebiasis
map05322Systemic lupus erythematosus
map04510Focal adhesion
map04530Tight junction
map04810Regulation of actin cytoskeleton
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001589
IPR001715
IPR002017
IPR002048
IPR011992
IPR014837

The S-nitrosylation sites of ACTN2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
148KQQRKTFTAW C NSHLRKAGTQ HHHHHHHHHH H HHHHHCCCCC 3.29%MC0122865876in vivo
2161TSAKEGLLLW C QRKTAPYRNV CCHHHHHHHH H HHHHCCCCCC 2.57%MC0122865876in vivo
3187HTSWKDGLGL C ALIHRHRPDL CCHHHHHHHH H HHHHHHCCCC 2.48%MC0221278135in vitro
4187HTSWKDGLGL C ALIHRHRPDL CCHHHHHHHH H HHHHHHCCCC 2.48%MC0222865876in vivo
5251DERAIMTYVS C FYHAFAGAEQ CHHHHHHHHH H HHHHCCCCCC 2.54%MC1222865876in vivo
6339KHKPPKVQEK C QLEINFNTLQ CCCCHHHHHC C HHHHHHHHHH 5.70%MC0822865876in vivo
7487VNVNDRCQKI C DQWDRLGTLT HHHHHHHHHH H HHHHHHHHHH 4.02%MC0421278135in vitro
8487VNVNDRCQKI C DQWDRLGTLT HHHHHHHHHH H HHHHHHHHHH 4.02%MC0422865876in vivo
9781GLMDHEDFRA C LISMGYDLGE CCCCHHHHHH H HHHCCCCCCH 2.78%MC0922865876in vivo
10862RELPPDQAQY C IKRMPPYSGP HHCCHHHHHH H HHHHHHHCCC 1.64%MC0622865876in vivo