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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Alpha-actinin-4

UniprotKB/SwissProt ID: ACTN4_HUMAN (O43707)

Gene Name: ACTN4

Organism: Homo sapiens (Human).

Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Cell junction (By similarity). Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochal

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD05222Glomerulosclerosis, focal segmental, 1
Network with metabolic pathway:
Kegg map ID Pathway Link
map05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
map04520Adherens junction
map04670Leukocyte transendothelial migration
map05146Amoebiasis
map05322Systemic lupus erythematosus
map04510Focal adhesion
map04530Tight junction
map04810Regulation of actin cytoskeleton
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001589
IPR001715
IPR002017
IPR002048
IPR011992
IPR014837

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1WLX NMR - A519-645Link
1YDI X-ray 1.80 A B734-757Link
2R0O X-ray 2.20 A A/B47-271Link

The S-nitrosylation sites of ACTN4_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1351VHKPPKVQEK C QLEINFNTLQ HHCCCCCCCC C CHHHHHHHHH 5.70%HC0222178444-
2499HNVNTRCQKI C DQWDALGSLT HHHHHHHHHH H HHHHHHHHHH 4.02%HC0322178444-
3499HNVNTRCQKI C DQWDALGSLT HHHHHHHHHH H HHHHHHHHHH 4.02%HC0320140087in vivo
4793GALGPEEFKA C LISLGYDVEN CCCCHHHHHH H HHHCCCCCCC 3.41%HC0922178444-
5793GALGPEEFKA C LISLGYDVEN CCCCHHHHHH H HHHCCCCCCC 3.41%HC0920140087in vivo