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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

UniprotKB/SwissProt ID: ACY3_MOUSE (Q91XE4)

Gene Name: Acy3

Synonyms: Aspa2

Organism: Mus musculus (Mouse).

Function: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00250"Alanine, aspartate and glutamate metabolism"
map00340Histidine metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR007036

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3NFZ X-ray 2.15 A A1-318Link
3NH4 X-ray 2.00 A A1-318Link
3NH5 X-ray 2.09 A A1-318Link
3NH8 X-ray 2.80 A A1-318Link

The S-nitrosylation sites of ACY3_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1175SVESISKNGI C LEMGPQPQGV EHHHHCCCCC E EEECCCCCCC 2.52%MC1021278135in vitro