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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Alcohol dehydrogenase class-3

UniprotKB/SwissProt ID: ADHX_MOUSE (P28474)

Gene Name: Adh5

Synonyms: Adh-2, Adh2

Organism: Mus musculus (Mouse).

Function: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00010Glycolysis / Gluconeogenesis
map00071Fatty acid metabolism
map00350Tyrosine metabolism
map00830Retinol metabolism
map00980Metabolism of xenobiotics by cytochrome P450
map00982Drug metabolism - cytochrome P450
map05204Chemical carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002085
IPR002328
IPR011032
IPR013149
IPR013154
IPR014183
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1OTQ Model - A1-374Link
The S-nitrosylation sites of ADHX_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1195NTAKVEPGST C AVFGLGGVGL HHCCCCCCCE E EEECCCHHHH 3.05%MC0122865876in vivo
2211GGVGLAVIMG C KVAGASRIIG CHHHHHHHHH H HHCCCCEEEE 1.45%MC0522865876in vivo
3240AKAKEFGASE C ISPQDFSKSI HHHHHCCCCE E ECCCCCCHHH 3.28%MC0121278135in vitro