UniprotKB/SwissProt ID: AIFM1_MOUSE (Q9Z0X1)
Gene Name: Aifm1
Synonyms: Aif, Pdcd8
Organism: Mus musculus (Mouse).
Function: Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis,and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion intermembrane space. Mitochondrion inner membrane (By similarity). Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus. Note=Proteolytic cleavage during or just after translocation into the mitochondrial interm
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