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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: AH receptor-interacting protein

UniprotKB/SwissProt ID: AIP_HUMAN (O00170)

Gene Name: AIP

Synonyms: XAP2

Organism: Homo sapiens (Human).

Function: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Cellular negative regulator of the hepatitis B virus (HBV) X protein.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

Protein disease:
Disease database Database Entry Disease information
HPRD10408Pituitary adenoma predisposition
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001179
IPR011990
IPR013026
IPR013105

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2LKN NMR - A2-166Link
4AIF X-ray 2.01 A A/B173-315Link
4APO X-ray 1.90 A A/B166-330Link

The S-nitrosylation sites of AIP_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1208AAAKYYDAIA C LKNLQMKEQP HHHHHHHHHH H HCCCCCCCCC 4.55%HC0119483679in vivo
2238QQITPLLLNY C QCKLVVEEYY HHHHHHHHHH H HHHHHHCCHH 3.59%HC0619483679in vivo
3240ITPLLLNYCQ C KLVVEEYYEV HHHHHHHHHH H HHHHCCHHHH 3.08%HC1219483679in vivo