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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: ADP-ribosylation factor 6

UniprotKB/SwissProt ID: ARF6_HUMAN (P62330)

Gene Name: ARF6

Organism: Homo sapiens (Human).

Function: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor (Probable). Cell projection, filopodium membrane; Lipid-anchor. Midbody (By similarity). Cytoplasm (By similarity). Cleavage furrow

PDB :
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Protein disease:
Disease database Database Entry Disease information
OMIM600464ADP-RIBOSYLATION FACTOR 6; ARF6
Network with metabolic pathway:
Kegg map ID Pathway Link
map04666Fc gamma R-mediated phagocytosis
map04144Endocytosis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001806
IPR005225
IPR006688
IPR006689