UniprotKB/SwissProt ID: ARHG7_MOUSE (Q9ES28)
Gene Name: Arhgef7
Synonyms: Kiaa0142, Pak3bp
Organism: Mus musculus (Mouse).
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
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