Protein Name: Rho guanine nucleotide exchange factor 12
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UniprotKB/SwissProt ID: ARHGC_HUMAN (Q9NZN5)
Gene Name: ARHGEF12
Synonyms: KIAA0382, LARG
Organism: Homo sapiens (Human).
Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm (Probable). Membrane (Probable). Note=Translocated to the membrane upon stimulation (Probable).
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 601626 | LEUKEMIA, ACUTE MYELOID; AML ;;LEUKEMIA, ACUTE MYELOGENOUS | | OMIM | 604763 | RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; ARHGEF12 ;;RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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