logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Aflatoxin B1 aldehyde reductase member 2

UniprotKB/SwissProt ID: ARK72_MOUSE (Q8CG76)

Gene Name: Akr7a2

Synonyms: Afar, Akr7a5

Organism: Mus musculus (Mouse).

Function: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein- binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus (By similarity). Cytoplasm (By similarity).

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00980Metabolism of xenobiotics by cytochrome P450
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001395

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2C91 X-ray 2.30 A A/B/C/D/E/F/G/H/I/J30-367Link

The S-nitrosylation sites of ARK72_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
186HSELDTAFMY C DGQSENILGG CCEEECHHHH C CCCCHHHHHH 2.96%MC1322865876in vivo
2106GLGLGLGSGD C TVKIATKANP HHHHHHCCCC C EEEEEEEEEE 5.56%MC0522865876in vivo
3164STPVEETLRA C HQLHQEGKFV CCCHHHHHHH H HHHHHCCCEE 1.37%MC0722865876in vivo
4190NYASWEVAEI C TLCKSNGWIL CCCHHHHHHH H HHHHHCCCCC 1.46%MC0722865876in vivo
5193SWEVAEICTL C KSNGWILPTV HHHHHHHHHH H HHCCCCCCEE 2.15%MC1322865876in vivo
6222TRQVEAELLP C LRHFGLRFYA CCHHHHHHHH H HHHCCCEEEE 5.42%MC0521278135in vitro