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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Actin-related protein 3

UniprotKB/SwissProt ID: ARP3_HUMAN (P61158)

Gene Name: ACTR3

Synonyms: ARP3

Organism: Homo sapiens (Human).

Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).

PDB :
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Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004000
IPR015623

The S-nitrosylation sites of ARP3_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
18---MAGRLPA C VVDCGTGYTK ---CCCCCCE E EEECCCCEEE 2.64%HC122212679in vitro
212AGRLPACVVD C GTGYTKLGYA CCCCCEEEEE C CCCEEEEEEC 3.38%HC072212679in vitro