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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Actin-related protein 3

UniprotKB/SwissProt ID: ARP3_MOUSE (Q99JY9)

Gene Name: Actr3

Synonyms: Arp3

Organism: Mus musculus (Mouse).

Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton (By similarity). Cell projection (By similarity). Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (By similarity).

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004000
IPR015623

The S-nitrosylation sites of ARP3_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
134NTEPQFIIPS C IAIKESAKVG CCCCCEEECH H HEEECCCCCC 1.72%MC0721278135in vitro
2189PVAEGYVIGS C IKHIPIAGRD EEEECEECCC C CEECCCHHHH 3.97%MC0322865876in vivo
3235KAVKERYSYV C PDLVKEFNKY HHHHHHCCCC C CCHHHHHHHH 1.32%MC0124895380-
4408KDYEEIGPSI C RHNPVFGVMS HHHHHHCHHH H HCCCCCCCCC 4.20%MC0624926564-
5408KDYEEIGPSI C RHNPVFGVMS HHHHHHCHHH H HCCCCCCCCC 4.20%MC0620925432in vivo
6408KDYEEIGPSI C RHNPVFGVMS HHHHHHCHHH H HCCCCCCCCC 4.20%MC0621278135in vitro