Protein Name: Sphingomyelin phosphodiesterase
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UniprotKB/SwissProt ID: ASM_HUMAN (P17405)
Gene Name: SMPD1
Synonyms: ASM
Organism: Homo sapiens (Human).
Function: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome.
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | HPRD | 06353 | Niemann-Pick disease, intermediate form, with macular halo | | HPRD | 06353 | Niemann-Pick disease, type A | | HPRD | 06353 | Niemann-Pick disease, type B |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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