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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Sodium/potassium-transporting ATPase subunit alpha-2

UniprotKB/SwissProt ID: AT1A2_MOUSE (Q6PIE5)

Gene Name: Atp1a2

Organism: Mus musculus (Mouse).

Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04960Aldosterone-regulated sodium reabsorption
map04961Endocrine and other factor-regulated calcium reabsorption
map04964Proximal tubule bicarbonate reclamation
map04973Carbohydrate digestion and absorption
map04978Mineral absorption
map04260Cardiac muscle contraction
map04970Salivary secretion
map04971Gastric acid secretion
map04972Pancreatic secretion
map04974Protein digestion and absorption
map04976Bile secretion
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001757
IPR004014
IPR005775
IPR005834
IPR006068
IPR006069
IPR008250

The S-nitrosylation sites of AT1A2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1209ADLRIISSHG C KVDNSSLTGE ECEEEEECCC E EEEECCCCCC 3.04%MC1124895380-
2209ADLRIISSHG C KVDNSSLTGE ECEEEEECCC E EEEECCCCCC 3.04%MC1121278135in vitro
3241HENPLETRNI C FFSTNCVEGT CCCCCCCCCE E EECEEEECCE 3.00%MC1322588120-
4241HENPLETRNI C FFSTNCVEGT CCCCCCCCCE E EECEEEECCE 3.00%MC1324895380-
5247TRNICFFSTN C VEGTARGIVI CCCEEEECEE E ECCEEEEEEE 2.74%MC0222588120-
6247TRNICFFSTN C VEGTARGIVI CCCEEEECEE E ECCEEEEEEE 2.74%MC0224895380-
7372VETLGSTSTI C SDKTGTLTQN HHHHHCCCEE E ECCCCCCCCC 4.33%MC1222588120-
8372VETLGSTSTI C SDKTGTLTQN HHHHHCCCEE E ECCCCCCCCC 4.33%MC1221278135in vitro
9372VETLGSTSTI C SDKTGTLTQN HHHHHCCCEE E ECCCCCCCCC 4.33%MC1222865876in vivo
10457GDASESALLK C IELSCGSVRK CCCHHHHHHH H HHHHCCCHHH 2.70%MC0324895380-
11462SALLKCIELS C GSVRKMRDRN HHHHHHHHHH C CCHHHHHCCC 8.02%MC0324895380-
12515KGAPERILDR C STILVQGKEI ECCHHHHHHH H HHHHHCCCCC 4.14%MC1324895380-
13553GGLGERVLGF C QLNLPSGKFP HHCCCEEEEE E EEECCCCCCC 4.22%MC1322588120-
14553GGLGERVLGF C QLNLPSGKFP HHCCCEEEEE E EEECCCCCCC 4.22%MC1324895380-
15581DELNFPTEKL C FVGLMSMIDP HHHHCCCCCC E EEEEEEECCC 3.73%MC0922865876in vivo
16660SQVNPREAKA C VVHGSDLKDM HHHCCCCCCC E EECHHHHHHH 3.02%MC0924895380-
17660SQVNPREAKA C VVHGSDLKDM HHHCCCCCCC E EECHHHHHHH 3.02%MC0921278135in vitro
18660SQVNPREAKA C VVHGSDLKDM HHHCCCCCCC E EECHHHHHHH 3.02%MC0922865876in vivo
19702PQQKLIIVEG C QRQGAIVAVT HHHHHHHHHH H HHCCCEEEEE 1.58%MC0122588120-
20702PQQKLIIVEG C QRQGAIVAVT HHHHHHHHHH H HHCCCEEEEE 1.58%MC0124895380-
21702PQQKLIIVEG C QRQGAIVAVT HHHHHHHHHH H HHCCCEEEEE 1.58%MC0121278135in vitro
22702PQQKLIIVEG C QRQGAIVAVT HHHHHHHHHH H HHCCCEEEEE 1.58%MC0122865876in vivo