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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Sodium/potassium-transporting ATPase subunit beta-2

UniprotKB/SwissProt ID: AT1B2_MOUSE (P14231)

Gene Name: Atp1b2

Organism: Mus musculus (Mouse).

Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Single-pass type II membrane protein.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04960Aldosterone-regulated sodium reabsorption
map04961Endocrine and other factor-regulated calcium reabsorption
map04964Proximal tubule bicarbonate reclamation
map04973Carbohydrate digestion and absorption
map04978Mineral absorption
map04260Cardiac muscle contraction
map04970Salivary secretion
map04971Gastric acid secretion
map04972Pancreatic secretion
map04974Protein digestion and absorption
map04976Bile secretion
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000402

The S-nitrosylation sites of AT1B2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
110-MVIQKEKKS C GQVVEEWKEF -CCCCCCCCC C CCCHHHHHHH 6.41%MC0922588120-
210-MVIQKEKKS C GQVVEEWKEF -CCCCCCCCC C CCCHHHHHHH 6.41%MC0924895380-
3129DSIQAQKNDV C RPGRYYEQPD CCCHHHCCCC C CCCCCCCCCC 4.91%MC0724895380-
4261VTPNVEVNVE C RINAANIATD CCCCEEEEEE E EECCCCCCCC 4.63%MC1322588120-