Protein Name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
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UniprotKB/SwissProt ID: AT2A2_HUMAN (P16615)
Gene Name: ATP2A2
Synonyms: ATP2B
Organism: Homo sapiens (Human).
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | KEGG | H00715 | Darier disease; Dyskeratosis follicularis | | KEGG | H00755 | Acrokeratosis verruciformis | | OMIM | 101900 | ACROKERATOSIS VERRUCIFORMIS; AKV ;;HOPF DISEASE | | OMIM | 108740 | ATPase, Ca(2)-TRANSPORTING, SLOW-TWITCH; ATP2A2 ;;ATP2B;; SARCOPLASMIC RETICULUM Ca(2)-ATP | | OMIM | 124200 | DARIER-WHITE DISEASE; DAR ;;KERATOSIS FOLLICULARIS;; DARIER DISEASE; DD DARIER DISEASE, ACRA | | HPRD | 00161 | Acrokeratosis verruciformis | | HPRD | 00161 | Darier disease | | HPRD | 00161 | Darier disease, acral hemorrhagic type | | HPRD | 00161 | Darier disease, segmental |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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