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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: ATP synthase subunit gamma, mitochondrial

UniprotKB/SwissProt ID: ATPG_MOUSE (Q91VR2)

Gene Name: Atp5c1

Organism: Mus musculus (Mouse).

Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00190Oxidative phosphorylation
map05010Alzheimer's disease
map05012Parkinson's disease
map05016Huntington's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000131

The S-nitrosylation sites of ATPG_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1103IIGVSSDRGL C GAIHSSVAKQ EEEEECCCCC H HHHHHHHHHH 3.73%MC0322178444-
2103IIGVSSDRGL C GAIHSSVAKQ EEEEECCCCC H HHHHHHHHHH 3.73%MC0321278135in vitro
3103IIGVSSDRGL C GAIHSSVAKQ EEEEECCCCC H HHHHHHHHHH 3.73%MC0320837516in vivo
4103IIGVSSDRGL C GAIHSSVAKQ EEEEECCCCC H HHHHHHHHHH 3.73%MC0322865876in vivo