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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: ATP synthase subunit O, mitochondrial

UniprotKB/SwissProt ID: ATPO_MOUSE (Q9DB20)

Gene Name: Atp5o

Synonyms: D12Wsu28e

Organism: Mus musculus (Mouse).

Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion (By similarity). Mitochondrion inner membrane (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00190Oxidative phosphorylation
map05010Alzheimer's disease
map05012Parkinson's disease
map05016Huntington's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000711

The S-nitrosylation sites of ATPO_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1141IMSVHRGEVP C TVTTASPLDD HHHHHHCEEE E EEEEECCCCH 6.04%MC1322588120-
2141IMSVHRGEVP C TVTTASPLDD HHHHHHCEEE E EEEEECCCCH 6.04%MC1321278135in vitro
3141IMSVHRGEVP C TVTTASPLDD HHHHHHCEEE E EEEEECCCCH 6.04%MC1322865876in vivo