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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Band 3 anion transport protein

UniprotKB/SwissProt ID: B3AT_HUMAN (P02730)

Gene Name: SLC4A1

Synonyms: AE1, DI, EPB3

Organism: Homo sapiens (Human).

Function: Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein.

PDB :
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Protein disease:
Disease database Database Entry Disease information
KEGGH00230 Hereditary spherocytosis (SPH)
KEGGH00231 Hereditary elliptocytosis (HE)
KEGGH00232 Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary
KEGGH00428 Distal renal tubular acidosis (RTA type 1)
OMIM109270SOLUTE CARRIER FAMILY 4 (ANION EXCHANGER), MEMBER 1; SLC4A1 ;;BAND 3 OF RED CELL MEMBRANE; B
OMIM110500BLOOD GROUP--DIEGO SYSTEM; DI ;;DIEGO BLOOD GROUP
OMIM112010BLOOD GROUP--WALDNER TYPE; WD ;;WALDNER BLOOD GROUP ANTIGEN
OMIM112050BLOOD GROUP--WRIGHT ANTIGEN; WR ;;WRIGHT BLOOD GROUP ANTIGEN
OMIM179800RENAL TUBULAR ACIDOSIS, DISTAL, AUTOSOMAL DOMINANT ;;RTA, DISTAL TYPE, AUTOSOMAL DOMINANT;;
OMIM601550BLOOD GROUP--SWANN SYSTEM; SW ;;SWANN BLOOD GROUP
OMIM601551BLOOD GROUP--FROESE ;;FR;; FROESE BLOOD GROUP ANTIGEN
OMIM611162MALARIA, SUSCEPTIBILITY TO MALARIA, RESISTANCE TO, INCLUDED;; MALARIA, SEVERE, SUSCEPTIBILIT
OMIM611590RENAL TUBULAR ACIDOSIS, DISTAL, WITH HEMOLYTIC ANEMIA ;;RTA, DISTAL, AUTOSOMAL RECESSIVE, WI
OMIM612653SPHEROCYTOSIS, TYPE 4; SPH4 ;;SPHEROCYTOSIS, HEREDITARY, 4; HS4
HPRD00175Band 3 Memphis
HPRD00175Diego blood group Antigen
HPRD00175Froese blood group antigen
HPRD00175Hemolytic anemia due to band 3 Montefiore
HPRD00175Ovalocytosis, southeast asian
HPRD00175Renal tubular acidosis, autosomal dominant
HPRD00175Renal tubular acidosis, distal, autosomal dominant
HPRD00175Renal tubular acidosis, distal, autosomal recessive
HPRD00175Spherocytosis, hereditary
HPRD00175Spherocytosis, hereditary, due to band 3 Cape Town
HPRD00175Spherocytosis, hereditary, due to band 3 Chur
HPRD00175Spherocytosis, hereditary, due to band 3 Fukuoka
HPRD00175Spherocytosis, hereditary, due to band 3 Genas
HPRD00175Spherocytosis, hereditary, due to band 3 Lyon
HPRD00175Spherocytosis, hereditary, due to band 3 Noirterre
HPRD00175Spherocytosis, hereditary, due to band 3 Prague
HPRD00175Spherocytosis, hereditary, due to band 3 Prague ii
HPRD00175Spherocytosis, hereditary, due to band 3 Prague III
HPRD00175Spherocytosis, hereditary, due to band 3 Tokyo
HPRD00175Spherocytosis, hereditary, due to band 3 Tuscaloosa
HPRD00175Swann blood group antigen
HPRD00175Waldner blood group antigen
HPRD00175Wright blood group Antigen
Network with metabolic pathway:
Kegg map ID Pathway Link
map04966Collecting duct acid secretion
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001717
IPR002977
IPR003020
IPR011531
IPR013769
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1BH7 NMR - A803-835Link
1BNX NMR - A389-430Link
1BTQ NMR - A405-424Link
1BTR NMR - A405-424Link
1BTS NMR - A436-456Link
1BTT NMR - A436-456Link
1BZK NMR - A389-430Link
1HYN X-ray 2.60 A P/Q/R/S1-379Link
2BTA NMR - A1-15Link
2BTB NMR - A1-15Link
3BTB NMR - A1-15Link
4KY9 X-ray 2.23 A A/P51-356Link
The S-nitrosylation sites of B3AT_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1201QHSSLETQLF C EQGDGGTEGH CCCCCCCCCC C CCCCCCCCCC 5.33%HC1222178444-
2201QHSSLETQLF C EQGDGGTEGH CCCCCCCCCC C CCCCCCCCCC 5.33%HC1211890743in vitro
3317LLHSLEGFLD C SLVLPPTDAP HHHHHHHHHC C EEECCCCCCC 3.54%HC0722178444-
4317LLHSLEGFLD C SLVLPPTDAP HHHHHHHHHC C EEECCCCCCC 3.54%HC0711890743in vitro