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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Branched-chain-amino-acid aminotransferase, mitochondrial

UniprotKB/SwissProt ID: BCAT2_HUMAN (O15382)

Gene Name: BCAT2

Synonyms: BCATM, BCT2, ECA40

Organism: Homo sapiens (Human).

Function: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform A: Mitochondrion. Isoform B: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00280"Valine, leucine and isoleucine degradation"
map00290"Valine, leucine and isoleucine biosynthesis"
map00770Pantothenate and CoA biosynthesis
map012102-Oxocarboxylic acid metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001544
IPR005786

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1EKF X-ray 1.95 A A/B28-392Link
1EKP X-ray 2.50 A A/B28-392Link
1EKV X-ray 2.25 A A/B28-392Link
1KT8 X-ray 1.90 A A/B28-392Link
1KTA X-ray 1.90 A A/B28-392Link
2A1H X-ray 1.80 A A/B28-392Link
2HDK X-ray 2.40 A A/B28-392Link
2HG8 X-ray 1.80 A A/B28-392Link
2HGW X-ray 1.98 A A/B28-392Link
2HGX X-ray 1.80 A A/B28-392Link
2HHF X-ray 1.80 A A/B28-392Link

The S-nitrosylation sites of BCAT2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1135DRMLRSAMRL C LPSFDKLELL HHHHHHHHHH C CCCCCHHHHH 3.56%HC0325040305in vivo
2342VREVFGSGTA C QVCPVHRILY CCEEEEECCE E EEEEEEEEEE 2.90%HC1019483679in vivo
3345VFGSGTACQV C PVHRILYKDR EEEECCEEEE E EEEEEEECCC 0.89%HC0619483679in vivo