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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Calpain-2 catalytic subunit

UniprotKB/SwissProt ID: CAN2_HUMAN (P17655)

Gene Name: CAPN2

Synonyms: CANPL2

Organism: Homo sapiens (Human).

Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
OMIM114230CALPAIN 2; CAPN2 ;;CALPAIN, LARGE POLYPEPTIDE L2;; CALPAIN II, LARGE SUBUNIT; CANPL2;; CALCI
Network with metabolic pathway:
Kegg map ID Pathway Link
map04210Apoptosis
map04510Focal adhesion
map05010Alzheimer's disease
map04141Protein processing in endoplasmic reticulum
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000169
IPR001300
IPR002048
IPR011992

The S-nitrosylation sites of CAN2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
182GIEWKRPTEI C ADPQFIIGGA CCEEECCHHH C CCCEEEECCC 2.60%HC122212679in vitro
2577IKSDGFSIET C KIMVDMLDSD CCCCCCCHHH H HHHHHHHCCC 1.50%HC122212679in vitro