UniprotKB/SwissProt ID: CAPZB_MOUSE (P47757)
Gene Name: Capzb
Synonyms: Cappb1
Organism: Mus musculus (Mouse).
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton (By similarity). Isoform 1: Cytoplasm, myofibril, sarcomere, Z line (By similarity). Cytoplasm, myofibril, sarcomere (By similarity). Note=In cardiac muscle, isoform 1 is located at Z- disks of sarcomeres while isoform 2 is enrich
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