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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cathepsin B

UniprotKB/SwissProt ID: CATB_HUMAN (P07858)

Gene Name: CTSB

Synonyms: CPSB

Organism: Homo sapiens (Human).

Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Lysosome. Melanosome. Secreted, extracellular space (By similarity). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04612Antigen processing and presentation
map04142Lysosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000169
IPR000668
IPR012599
IPR013128
IPR015643

The S-nitrosylation sites of CATB_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1211EGDTPKCSKI C EPGYSPTYKQ CCCCCCCCCC C CCCCCCCEEE 6.24%HC092212679in vitro
2319FFKILRGQDH C GIESEVVAGI EEEEEECCCC C CHHHHHHCCC 8.70%HC0225040305in vivo