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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cathepsin K

UniprotKB/SwissProt ID: CATK_HUMAN (P43235)

Gene Name: CTSK

Synonyms: CTSO, CTSO2

Organism: Homo sapiens (Human).

Function: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Lysosome.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD03064Pycnodysostosis
Network with metabolic pathway:
Kegg map ID Pathway Link
map04380Osteoclast differentiation
map05323Rheumatoid arthritis
map04142Lysosome
map04620Toll-like receptor signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000169
IPR000668
IPR013128
IPR013201
IPR015644
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1ATK X-ray 2.20 A A115-329Link
1AU0 X-ray 2.60 A A115-329Link
1AU2 X-ray 2.60 A A115-329Link
1AU3 X-ray 2.50 A A115-329Link
1AU4 X-ray 2.30 A A115-329Link
1AYU X-ray 2.20 A A115-329Link
1AYV X-ray 2.30 A A115-329Link
1AYW X-ray 2.40 A A115-329Link
1BGO X-ray 2.30 A A115-329Link
1BY8 X-ray 2.60 A A16-329Link
1MEM X-ray 1.80 A A115-329Link
1NL6 X-ray 2.80 A A/B115-329Link
1NLJ X-ray 2.40 A A/B115-329Link
1Q6K X-ray 2.10 A A115-329Link
1SNK X-ray 2.40 A A116-329Link
1TU6 X-ray 1.75 A A/B115-329Link
1U9V X-ray 2.20 A A113-329Link
1U9W X-ray 2.30 A A113-329Link
1U9X X-ray 2.10 A A113-329Link
1VSN X-ray 2.00 A A115-329Link
1YK7 X-ray 2.50 A A115-329Link
1YK8 X-ray 2.60 A A115-329Link
1YT7 X-ray 2.30 A A115-329Link
2ATO X-ray 2.00 A A115-329Link
2AUX X-ray 2.40 A A115-329Link
2AUZ X-ray 2.30 A A115-329Link
2BDL X-ray 2.00 A A115-329Link
2R6N X-ray 1.95 A A113-329Link
3C9E X-ray 1.80 A A115-329Link
3H7D X-ray 2.24 A A/E115-329Link
3KW9 X-ray 1.80 A A115-329Link
3KWB X-ray 2.02 A X/Y115-329Link
3KWZ X-ray 1.49 A A115-329Link
3KX1 X-ray 1.51 A A115-329Link
3O0U X-ray 1.80 A A115-329Link
3O1G X-ray 1.65 A A115-329Link
3OVZ X-ray 2.02 A A121-329Link
4DMX X-ray 1.70 A A115-329Link
4DMY X-ray 1.63 A A/B115-329Link
4LEG X-ray 2.60 A A107-329Link
7PCK X-ray 3.20 A A/B/C/D16-329Link
The S-nitrosylation sites of CATK_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1139PVKNQGQCGS C WAFSSVGALE CCCCCCCCCC H HHHHHHHHHH 1.52%HC0722178444-
2139PVKNQGQCGS C WAFSSVGALE CCCCCCCCCC H HHHHHHHHHH 1.52%HC0710521264in vitro