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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cathepsin S

UniprotKB/SwissProt ID: CATS_MOUSE (O70370)

Gene Name: Ctss

Synonyms: Cats

Organism: Mus musculus (Mouse).

Function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Lysosome.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000169
IPR000668
IPR013128
IPR013201

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1M0H Model - A1-340Link
4BS5 X-ray 1.25 A A116-340Link
4BSQ X-ray 1.96 A A116-340Link

The S-nitrosylation sites of CATS_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1281YKSGVYDDPS C TGNVNHGVLV CCCCEEECCC C CCCCCEEEEE 7.41%MC0222178444-
2281YKSGVYDDPS C TGNVNHGVLV CCCCEEECCC C CCCCCEEEEE 7.41%MC0219483679in vivo
3329IRMARNNKNH C GIASYCSYPE EEEEECCCCC C EEECCCCCCC 6.19%MC0822178444-
4329IRMARNNKNH C GIASYCSYPE EEEEECCCCC C EEECCCCCCC 6.19%MC0819483679in vivo
5335NKNHCGIASY C SYPEI----- CCCCCEEECC C CCCCC 2.66%MC0122178444-
6335NKNHCGIASY C SYPEI----- CCCCCEEECC C CCCCC 2.66%MC0119483679in vivo