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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Caveolin-3

UniprotKB/SwissProt ID: CAV3_MOUSE (P51637)

Gene Name: Cav3

Organism: Mus musculus (Mouse).

Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Membrane, caveola; Peripheral membrane protein (By similarity). Note=Potential hairpin-like structure in the membrane. Memb

Network with metabolic pathway:
Kegg map ID Pathway Link
map05100Bacterial invasion of epithelial cells
map04510Focal adhesion
map04144Endocytosis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001612

The S-nitrosylation sites of CAV3_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
119LEARIIKDIH C KEIDLVNRDP HHHHHHHHCC C CEEECCCCCH 4.29%MC0121278135in vitro