Protein Name: Cystathionine beta-synthase
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UniprotKB/SwissProt ID: CBS_HUMAN (P35520)
Gene Name: CBS
Organism: Homo sapiens (Human).
Function: Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus.
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | HPRD | 01994 | Homocystinuria | | HPRD | 01994 | Homocystinuria, pyridoxine-responsive | | HPRD | 01994 | Thrombosis, hyperhomocysteinemic |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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