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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cell division cycle protein 16 homolog

UniprotKB/SwissProt ID: CDC16_MOUSE (Q8R349)

Gene Name: Cdc16

Synonyms: Anapc6

Organism: Mus musculus (Mouse).

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map04110Cell cycle
map04114Oocyte meiosis
map04914Progesterone-mediated oocyte maturation
map05166HTLV-I infection
map04120Ubiquitin mediated proteolysis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001440
IPR011990
IPR013026

The S-nitrosylation sites of CDC16_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1133MSQSSIKSSI C LLRGKIYDAL HHHCCCHHHH H HHHHHHHHHC 2.94%MC0421278135in vitro