UniprotKB/SwissProt ID: CFLAR_HUMAN (O15519)
Gene Name: CFLAR
Synonyms: CASH, CASP8AP1, CLARP, MRIT
Organism: Homo sapiens (Human).
Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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PDB :
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