Protein Name: Calcium-activated chloride channel regulator 1
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UniprotKB/SwissProt ID: CLCA1_HUMAN (A8K7I4)
Gene Name: CLCA1
Synonyms: CACC1
Organism: Homo sapiens (Human).
Function: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
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Protein disease:
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Disease database |
Database Entry |
Disease information | OMIM | 603906 | CHLORIDE CHANNEL, CALCIUM-ACTIVATED, 1; CLCA1 ;;GOB5 |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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