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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Calcium-activated chloride channel regulator 1

UniprotKB/SwissProt ID: CLCA1_HUMAN (A8K7I4)

Gene Name: CLCA1

Synonyms: CACC1

Organism: Homo sapiens (Human).

Function: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.

Protein disease:
Disease database Database Entry Disease information
OMIM603906CHLORIDE CHANNEL, CALCIUM-ACTIVATED, 1; CLCA1 ;;GOB5
Network with metabolic pathway:
Kegg map ID Pathway Link
map04740Olfactory transduction
map04972Pancreatic secretion
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of CLCA1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1187LSNGRIQAVR C SAGITGTNVV   2.35%HC0225040305in vivo
2308SLLQIGQRIV C LVLDKSGSMA   1.70%HC0425040305in vivo