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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Clathrin heavy chain 1

UniprotKB/SwissProt ID: CLH1_HUMAN (Q00610)

Gene Name: CLTC

Synonyms: CLH17, CLTCL2, KIAA0034

Organism: Homo sapiens (Human).

Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
OMIM118955CLATHRIN, HEAVY POLYPEPTIDE; CLTC ;;CLATHRIN HEAVY CHAIN; CHC CLTC/TFE3 FUSION GENE, INCLUDE
Network with metabolic pathway:
Kegg map ID Pathway Link
map04721Synaptic vesicle cycle
map04961Endocrine and other factor-regulated calcium reabsorption
map05100Bacterial invasion of epithelial cells
map04142Lysosome
map05016Huntington's disease
map04144Endocytosis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000547
IPR001473
IPR011990
IPR015348

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2XZG X-ray 1.70 A A1-364Link
4G55 X-ray 1.69 A A1-364Link

The S-nitrosylation sites of CLH1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1151MFDRHSSLAG C QIINYRTDAK HHHCCCCCCC C EEEEEEECCC 1.87%HC0119483679in vivo
2491RANVPNKVIQ C FAETGQVQKI ECCCCHHHHH H HHHHHHHHHH 2.10%HC0819483679in vivo
3736DVHFKYIQAA C KTGQIKEVER HHHHHHHHHH H HHCHHHHHHH 4.55%HC0719483679in vivo
4918YCEKRDPHLA C VAYERGQCDL HHCCCCCCEE E EEEECCCCHH 1.96%HC0119483679in vivo
5926LACVAYERGQ C DLELINVCNE EEEEEEECCC C HHHHHHHHCC 7.79%HC0419483679in vivo
6934GQCDLELINV C NENSLFKSLS CCCHHHHHHH H CCHHHHHHHH 4.58%HC1019483679in vivo
71102LDRAYEFAER C NEPAVWSQLA HHHHHHHHHH C CCHHHHHHHH 5.21%HC022212679in vitro