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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Clathrin heavy chain 1

UniprotKB/SwissProt ID: CLH1_MOUSE (Q68FD5)

Gene Name: Cltc

Organism: Mus musculus (Mouse).

Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Melanosome (By similarity). Note=Cytoplasmic face of coated pits and vesicle

Network with metabolic pathway:
Kegg map ID Pathway Link
map04721Synaptic vesicle cycle
map04961Endocrine and other factor-regulated calcium reabsorption
map05100Bacterial invasion of epithelial cells
map04142Lysosome
map05016Huntington's disease
map04144Endocytosis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of CLH1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1151MFDRHSSLAG C QIINYRTDAK   %MC0122588120-
2151MFDRHSSLAG C QIINYRTDAK   %MC0124895380-
3151MFDRHSSLAG C QIINYRTDAK   %MC0122865876in vivo
4491RANVPNKVIQ C FAETGQVQKI   %MC0322588120-
5491RANVPNKVIQ C FAETGQVQKI   %MC0324895380-
6926LACVAYERGQ C DLELINVCNE   %MC1322588120-
7926LACVAYERGQ C DLELINVCNE   %MC1324895380-
8926LACVAYERGQ C DLELINVCNE   %MC1322865876in vivo
9934GQCDLELINV C NENSLFKSLS   %MC0522588120-
10934GQCDLELINV C NENSLFKSLS   %MC0522865876in vivo
111102LDRAYEFAER C NEPAVWSQLA   %MC1324895380-
121102LDRAYEFAER C NEPAVWSQLA   %MC1322865876in vivo