logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Chloride intracellular channel protein 1

UniprotKB/SwissProt ID: CLIC1_HUMAN (O00299)

Gene Name: CLIC1

Synonyms: G6, NCC27

Organism: Homo sapiens (Human).

Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Nucleus membrane; Single-pass membrane protein (Probable). Cytoplasm. Cell membrane; Single-pass membrane protein (Probable). Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Ex

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
OMIM602872CHLORIDE INTRACELLULAR CHANNEL 1; CLIC1 ;;NCC27
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002946
IPR004046
IPR012335
IPR012336

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1K0M X-ray 1.40 A A/B1-241Link
1K0N X-ray 1.80 A A/B1-241Link
1K0O X-ray 1.75 A A/B1-241Link
1RK4 X-ray 1.79 A A/B1-241Link
3O3T X-ray 1.70 A A1-241Link
3P8W X-ray 2.00 A A1-241Link
3P90 X-ray 2.30 A A1-241Link
3QR6 X-ray 1.78 A A1-241Link
3SWL X-ray 2.35 A A6-241Link
3TGZ X-ray 2.30 A A/B1-241Link
3UVH X-ray 1.84 A A/B1-241Link
4IQA X-ray 2.49 A A/B6-241Link

The S-nitrosylation sites of CLIC1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
124AGSDGAKIGN C PFSQRLFMVL CCCCCCCCCC C HHHHHHHHHH 2.80%HC1224105792-
259KRRTETVQKL C PGGQLPFLLY CCCHHHHHHH C CCCCCCEEEE 3.66%HC0324105792-
3178LDGNELTLAD C NLLPKLHIVQ CCCCHHHHHH H HHHHHHHHHH 3.00%HC1024105792-
4191LPKLHIVQVV C KKYRGFTIPE HHHHHHHHHH H HHHCCCCCCC 3.10%HC0524105792-
5191LPKLHIVQVV C KKYRGFTIPE HHHHHHHHHH H HHHCCCCCCC 3.10%HC0520140087in vivo