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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cofilin-1

UniprotKB/SwissProt ID: COF1_HUMAN (P23528)

Gene Name: CFL1

Synonyms: CFL

Organism: Homo sapiens (Human).

Function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
OMIM601442COFILIN 1; CFL1 ;;COFILIN, NONMUSCLE
Network with metabolic pathway:
Kegg map ID Pathway Link
map04360Axon guidance
map04666Fc gamma R-mediated phagocytosis
map05133Pertussis
map04810Regulation of actin cytoskeleton
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002108

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1Q8G NMR - A1-166Link
1Q8X NMR - A1-166Link
3J0S EM 9.00 A M/N/O/P/Q/R/S/T/U/V/W/X1-166Link
4BEX X-ray 2.80 A 11-166Link

The S-nitrosylation sites of COF1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
139VKKRKKAVLF C LSEDKKNIIL HCCCCEEEEE E ECCCCEEEEE 3.41%HC0124105792-
239VKKRKKAVLF C LSEDKKNIIL HCCCCEEEEE E ECCCCEEEEE 3.41%HC012212679in vitro
380TFVKMLPDKD C RYALYDATYE HHHHHCCCCC C EEEEEEEEEE 4.40%HC1124105792-
4139TGIKHELQAN C YEEVKDRCTL CCEEEEEEEC C HHHCCHHHHH 5.19%HC1124105792-
5139TGIKHELQAN C YEEVKDRCTL CCEEEEEEEC C HHHCCHHHHH 5.19%HC112212679in vitro
6147ANCYEEVKDR C TLAEKLGGSA ECCHHHCCHH H HHHHHCCCEE 5.40%HC0219483679in vivo