Protein Name: Catechol O-methyltransferase
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UniprotKB/SwissProt ID: COMT_HUMAN (P21964)
Gene Name: COMT
Organism: Homo sapiens (Human).
Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 116790 | CATECHOL-O-METHYLTRANSFERASE; COMT CATECHOL-O-METHYLTRANSFERASE ACTIVITY, LOW, IN RED CELLS, | | OMIM | 167870 | PANIC DISORDER 1; PAND1 ;;PANIC DISORDER SUSCEPTIBILITY LOCUS, CHROMOSOME 13q-RELATED;; PANI | | OMIM | 181500 | SCHIZOPHRENIA; SCZD ;;SCHIZOAFFECTIVE DISORDER, INCLUDED | | HPRD | 00284 | Catechol-O-methyltransferase polymorphism | | HPRD | 00284 | Schizophrenia, susceptibility to |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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