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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Coatomer subunit alpha

UniprotKB/SwissProt ID: COPA_HUMAN (P53621)

Gene Name: COPA

Organism: Homo sapiens (Human).

Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cyt

Protein disease:
Disease database Database Entry Disease information
OMIM601924COATOMER PROTEIN COMPLEX, SUBUNIT ALPHA; COPA ;;ALPHA COAT PROTEIN COATOMER PROTEIN COMPLEX,
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001680
IPR006692
IPR009033
IPR010714
IPR011046
IPR015943

The S-nitrosylation sites of COPA_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1245NESKAWEVDT C RGHYNNVSCA CCCCCEEEEE E ECCCCCEEEE 4.20%HC0122178444-
2245NESKAWEVDT C RGHYNNVSCA CCCCCEEEEE E ECCCCCEEEE 4.20%HC0116648260in vivo